Sameera Reddy made her debut as an actress in Saravana Subbiah’s Tamil film Citizen, during early 2000s, but eventually did not feature. The actress caught the attention of Bollywood and was cast in a pivotal role in the 2002 Hindi film Maine Dil Tujhko Diya. In 2004, she shared the screen space with Anil Kapoor in Musafir. Her popular movies are Darna Mana Hai, Musafir, Jai Chiranjeeva, Taxi Number 9211, Ashok, Race, Varanam Aayiram, De Dana Dan, Aakrosh, Vettai and Tezz. Sameera Reddy has also been the part of few Telugu and Tamil movies. She has worked with Young Tiger Jr NTR in Narasimhudu and with Chiranjeevi in Jai Chiranjeeva. In film Industry, she was last seen in Kannada movie Varadhanayaka, which was released in 2013.
Sameera Reddy is also the first Indian actress to have her own video game, Sameera the Street Fighter. This mobile video game can be downloaded by millions of fans and is available to cell phone users throughout India.
Sameera Reddy tied the knot with entrepreneur Akshai Varde in January 2014. Sameera is expecting a second baby and is four months pregnant. Recently during the media interaction, she herself confirmed the news that she is pregnant again and her due date is in July.